Bibliography of Articles on Proton Therapy

II. Applications for Proton Therapy (by disease)

Bladder
Eye
Pancreas
  Bone
Head & Neck
Children/Pediatric
  Brain
Hodgkin’s Disease
Prostate
  Breast
Liver
Rectum
  Cervix
Lung
Spine
  Esophagus Nerve  


Bladder

Hata Masahura, et al.
Proton Beam Therapy for Invasive Bladder Cancer: A Prospective Study of Bladder-Preserving Therapy with Combined Radiotherapy and Intra-Arterial Chemotherapy.
Int. J. Radiation Oncology Biol. Phys. 2006; 64(5): 1371–1379

Miralbell R.
Conformational radiotherapy for bladder cancer: limits to precision and potential advantages of the utilization of proton beams
Arch Esp Urol. 1999 Jul-Aug;52(6):684-91. Review. Spanish.
PMID: 10484852 [PubMed – indexed for MEDLINE]

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Bone

DeLaney Thomas F., et al.
Advanced-Technology Radiation Therapy in the Management of Bone and Soft Tissue Sarcomas.
Cancer Control. 2005 January/February; 12(1): 27-35.

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Brain

Amin-Hanjani S, Ogilvy CS, Candia GJ, Lyons S, Chapman PH.
Stereotactic radiosurgery for cavernous malformations: Kjellberg’s experience with proton beam therapy in 98 cases at the Harvard Cyclotron.
Neurosurgery. 1998 Jun;42(6):1229-36; discussion 1236-8.
PMID: 9632180 [PubMed – indexed for MEDLINE]

Barker FG 2nd, Butler WE, Lyons S, Cascio E, Ogilvy CS, Loeffler JS, Chapman PH.
Dose-volume prediction of radiation-related complications after proton beam radiosurgery for cerebral arteriovenous malformations.
J Neurosurg. 2003 Aug;99(2):254-63.
PMID: 12924697 [PubMed – indexed for MEDLINE]

Baumert BG, Lomax AJ, Miltchev V, Davis JB.
A comparison of dose distributions of proton and photon beams in stereotactic conformal radiotherapy of brain lesions.
Int J. Radiat Oncol Biol Phys. 2001 Apr 1;49(5):1439-49.
PMID: 11286852 [PubMed – indexed for MEDLINE]

Gridley DS, Li J, Kajoika EH, Andres ML, Moyers MF, Slater JM.
Combination of pGL1-TNF-alpha gene and radiation (proton and gamma-ray) therapy against brain tumor.
Anticancer Res. 2000 Nov-Dec;20(6B):4195-203.
PMID: 11205248 [PubMed – indexed for MEDLINE]

Gridley DS, Baer JR, Cao JD, Miller GM, Kim DW, Timiryasova TM, Fodor I,
Slater JM.
TNF-alpha gene and proton radiotherapy in an orthotopic brain tumor model.
Int J Oncol. 2002 Aug;21(2):251-9.
PMID: 12118318 [PubMed – indexed for MEDLINE]

Gridley DS, Miller GM, Luo X, Cao JD, Timiryasova TM, Fodor l, Slater JM.
Proton radiation and TNF-alpha/Bax gene therapy for orthotopic C6 brain tumor in Wistar rats.
Technol Cancer Res Treat. 2004 Apr;3(2):217-27.
PMID: 15059028 [PubMed – indexed for MEDLINE]

Lin R, Hug EB, Schaefer RA, Miller DW, Slater JM, Slater JD.
Conformal proton radiation therapy of the posterior fossa: a study comparing protons with three-dimensional planned protons in limiting dose to auditory structures.
Int J Radiat Oncol Biol Phys. 2000 Nov 1;48(4):1219-26.
PMID: 11072181 [PubMed – indexed for MEDLINE]

Porter RW, Detwiler PW, Han PP, Spetzler RF.
Stereotactic radiosurgery for cavernous malformations: Kjellberg’s experience with proton beam therapy in 98 cases at the Harvard Cyclotron.
Neurosurgery. 1999 Feb;44(2):424-5. No abstract available.
PMID: 9932903 [PubMed – indexed for MEDLINE]

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Breast

Fogliata A, Bolsi A, Cozzi L.
Critical appraisal of treatment techniques based on conventional photon beams, intensity modulated photon beams and proton beams for therapy of intact breast.
Radiother Oncol. 2002 Feb;62(2):137-45.
PMID: 11937240 [PubMed – indexed for MEDLINE]

Kozak Kevin R., et al.
Dosimetric Comparison of Proton and Photon Three-Dimensional, Conformal, External Beam Accelerated Partial Breast Irradiation Techniques.
Int. J. Radiation Oncology Biol. Phys. 2006; 65(5): 1572–1578.

Lomax Anthony J., et al.
Potential Role of Intensity-Modulated Photons and Protons in the Treatment of the Breast and Regional Nodes.
Int. J. Radiation Oncology Biol. Phys. 2003; 55(3): 785–792.

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Cervix

Kagei K, Tokuuye K. Okumura T, Ohara K, Shioyama Y, Sugahara S, Akine Y.
Long-term results of proton beam therapy for carcinoma of the uterine cervix.
Int J Radiat Oncol Biol Phys. 2003 Apr 1;55(5):1265-71.
PMID: 12654436 [PubMed – indexed for MEDLINE]

Slater JD, Slater JM, Wahlen S.
The potential for proton beam therapy in locally advanced carcinoma of the cervix.
Int J Radiat Oncol Biol Phys. 1992;22(2):343-7.
PMID: 1310969 [PubMed – indexed for MEDLINE]

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Esophagus

Isacsson U, Lennernas B, Grusell E, Jung B, Montelius A, Glimelius B.
Comparative treatment planning between proton and x-ray therapy in esophageal cancer.
Int J Radiat Oncol Biol Phys. 1998 May1;41(2):441-50.
PMID: 9607363 [PubMed – indexed for MEDLINE]

Koyama S, Tsujii H.
Proton beam therapy with high-dose irradiation for superficial and advanced esophageal carcinomas.
Clin Cancer Res. 2003 Sep 1;9(10 Pt 1):3571-7.
PMID: 14506143 [PubMed – indexed for MEDLINE]

Sugahara, Shinji, et al.
Clinical Results of Proton Beam Therapy of the Esophagus.
Int. J. Radiation Oncology Biol. Phys. 2005; 61(1): 76–84.

Sugahara S, Tokuuye K, Okumura T, Nakahara A, Saida Y, Kagei K, Ohara K, Hata
M, Igaki H, Akine Y.
Clinical results of proton beam therapy for cancer of the esophagus.
Int J Radiat Oncol Biol Phys. 2005 Jan 1;61(1):76-84.
PMID: 15629597 [PubMed – indexed for MEDLINE]

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Eye

Adams JA, Paiva KL, Munzenrider JE, Miller JW, Gragoudas ES.
Proton beam therapy for age-related macular degeneration: development of a standard plan.
Med Dosim. 1999 Winter;24(4):233-8.
PMID: 10643731 [PubMed – indexed for MEDLINE]

Bechrakis NE, Foerster MH.
Where is the superiority of proton radiation for ocular tumours?
Graefes Arch Clin Exp Ophthalmol. 2002 Jul;240(7):513-4. No abstract available.
PMID: 12269248 [PubMed – indexed for MEDLINE]

Chauvel P, Iborra-Brassart N, Courdi A, Herault J, Teissier E, Pignol JP, Bondiau
PY.
Proton therapy in ophthalmology: status report and problems encountered.
Bull Cancer Radiother. 1996;83 Suppl:215s-8s.
PMID: 8949783 [PubMed – indexed for MEDLINE]

Chauvel P, Sauerwein W, Bornfeld N, Freidrichs W, Brassart N, Courdi A,
Herault J, Pignol JP, Bondiau PY, Malandain G.
Clinical and technical requirements for proton treatment planning of ocular
diseases. The SERAG (South Europe Radiotherapy Group).
Front Radiat Ther Oncol. 1997;30:133-42. No abstract available.
PMID: 9205893 [PubMed – indexed for MEDLINE]

Cuilla TA, Danis RP, Klein SB, Malinovsky VE, Soni PS, Pratt LM, Pugh NO,
Morphis JG, Bloch C, Cameron J.
Proton therapy for exudative age-related macular degeneration: a randomized,
sham-controlled clinical trial.
AM J Ophthalmol. 2002 Dec;134(6):905-6.
PMID: 12470761 [PubMed – indexed for MEDLINE]

D’Hermies F, Meyer A, Morel X, Lumbroso L. Levy C, Desjardins L, Frau E, Halhal
M, Elmalch C, Berges O, Gauthier JB, Ferrand R, Delacroix S, Schlienger P, Schwarz L,
Habrand JL, Mazeron A, Renard G.
Neovascular glaucoma following proton-beam therapy. Case report
J Fr Opthalmol. 2001 Jan;24(1):95-101. French.
PMID: 11240479 [PubMed – indexed for MEDLINE]

Desjardins L, Levy C, d’Hermies F, Frau E, Schlienger P, Habrand JL, Mammar H, Schwartz L, Mazal A, Delacroix S, Nauraye C, Ferrand R, Asselain B.
Initial results of proton therapy in choroidal melanoma at the d’Orsey Center for Proton Therapy; the first 464 cases
Cancer Radiother. 1997;1(3):222-6. French.
PMID: 9295876 [PubMed – indexed for MEDLINE]

Devouassoux Shishe Boran M, Grange JD, Patricot LM, Adeleine P, Chauvel P,
Chiquet C, Vitrey D, Thivolet Bejui F.
Histopathologic study of melanoma of the choroid after proton therapy
Ann Pathol. 1997 Jul;17(3):187-92. French
PMID: 9296578 [PubMed – indexed for MEDLINE]

Dobler B, Bendl R.
Precise modelling of the eye for proton therapy of intra-ocular tumours.
Phys Med Biol. 2002 Feb 21;47(4):593-613.
PMID: 11900193 [PubMed – indexed for MEDLINE]

Egger Emmanuel, et al.
Eye Retention after Proton Beam Radiotherapy for Uveal Melanoma.
Int. J. Radiation Oncology Biol. Phys. 2003; 55(4): 867–880.

Frau E, Rumen F, Noel G, Delacroix S, Habrand JL, Offret H.
Low-dose proton beam therapy for circumscribed choroidal hemangiomas.
Arch Opthalmol. 2004 Oct;122(10):1471-5.
PMID: 15477458 [PubMed – indexed for MEDLINE]

Fuss M, Loredo LN, Blacharski PA, Grove RI, Slater JD.
Proton radiation therapy for medium and large choroidal melanoma: preservation of the eye and its functionality.
Int J Radiat Oncol Biol Phys. 2001 Mar 15;49(4):1053-9.
PMID: 11240247 [PubMed – indexed for MEDLINE]

Gambrelle J, Kodjikian L, Rouberol F, Donate D, Duquesne N, Jean-Louis B,
Chauvel P, Gerard JP, Romestaing P, Grange JD.
Ciliary body melanomas. Survival and prognostic aspects after brachytherapy or proton therapy
J Fr Opthalmol. 2004 Jan;27(1):40-7. French.
PMID: 14968076 [PubMed – indexed for MEDLINE]

Gear HC, Kemp EG, Kacperek A, Errington RD.
Treatment of recurrent orbital haemangiopericytoma with surgery and proton beam therapy.
Br J Opthalmol. 2005 Jan;89(1):123-4. No abstract available.
PMID: 15615763 [PubMed – indexed for MEDLINE]

Gragoudas ES, Lan AM, Munzenrider J, Egan KM, Li W.
Long-term risk of local failure after proton therapy for choroidal/ciliary body melanoma.
Trans Am Opthalmol Soc. 2002;100:43-8; discussion 48-9.
PMID: 12545676 [PubMed – indexed for MEDLINE]

Guyer DR, Mukai S, Egan KM, Seddon JM, Walsh SM, Gragoudas ES.
Radiation maculopathy after proton beam irradiation for choroidal melanoma.
Opthalmology. 1992 Aug;99(8):1278-85.
PMID: 1325044 [PubMed – indexed for MEDLINE]

Hannouche D, Frau E, Desjardins L, Cassoux N, Habrand JL, Offret H.
Efficacy of proton therapy in circumscribed choroidal hemangiomas associated with serious retinal detachment.
Ophthalmology. 1997 Nov;104(11):1780-4.
PMID: 9373107 [PubMed – indexed for MEDLINE]

Heufelder J, Cordini D, Fuchs H, Heese J, Homeyer H, Kluge H, Morgenstern H,
Hocht S, Nausner M, Bechrakis NE, Hinkelbein W, Foerster MH.
Five years of proton therapy of eye neoplasms at the Hahn-Meitner Institute, Berlin
Z Med Phys. 2004:14(1):64-71. German.
PMID: 15104012 [PubMed – indexed for MEDLINE]

Hug EB, Adams J, Ritzek M, De Vries A, Munzenrider JE.
Fractionated, three-dimensional, planning-assisted proton-radiation therapy for orbital rhabdomyosarcoma: a novel technique.
Int J Radiat Oncol Biol Phys. 2000 Jul 1;47(4):979-84.
PMID: 10863068 [PubMed – indexed for MEDLINE]

Hungerford JL, Foss AJ, Whelahan I, Errington RD, Kacperek A, Kongerud J.
Side effects of photon and proton radiotherapy for ocular melanoma.
Front Radiat Ther Oncol. 1997;30:298-93. No abstract available.
PMID: 9205912 [PubMed – indexed for MEDLINE]

Krengli M, Hug EB, Adams JA, Smith AR, Tarbell NJ, Munzenrider JE.
Proton radiation therapy for retinoblastoma: comparison of various intraocular tumor locations and beam arrangements.
Int J Radiat Oncol Biol Phys. 2005 Feb 1;61(2):583-93.
PMID: 15667981 [PubMed – indexed for MEDLINE]

Kunz H, Derz C, Tolxdorff T, Bernarding J.
Feature extraction and supervised classification of MR images to support proton radiation therapy of eye tumors.
Comput Methods Programs Biomed. 2004 Mar; 73(3):195-202.
PMID: 14980401 [PubMed – indexed for MEDLINE]

Lee V, Hungerford JL.
Proton beam therapy for posterior pole circumscribed choroidal haemangioma.
Eye. 1998;12 (Pt 6):925-8.
PMID: 10325987 [PubMed – indexed for MEDLINE]

Li W, Gragoudas ES, Egan KM.
Tumor basal arca and metastatic death after proton beam irradiation for choroidal melanoma.
Arch Opthalmol. 2003 Jan;121(1):68-72.
PMID: 12523887 [PubMed – indexed for MEDLINE]

Mcderby MJ, John NW, Brunt JN, Kacperek A.
Modelling concepts of proton eye radiotherapy.
Physiol Meas. 2001 Aug;22(3):611-23.
PMID: 11556679 [PubMed – indexed for MEDLINE]

Meyer A. Levy C, Blondel J. D’hermies F, Frau E, Schlienger P, Mammar H,
Delacroix S, Nauraye C, Desblancs C, Ferrand R, Mazal A, Asselain B, Plancher C, Habrand J, Desjardins L.
Optic neuropathy after proton-beam therapy for malignant choroidal melanoma
J Fr Opthalmol. 2000 Jun;23(6):543-53. French.
PMID: 10880919 [PubMed – indexed for MEDLINE]

Miralbell R, Cella L, Weber D, Lomax A.
Optimizing radiotherapy of orbital and paraorbital tumors: intensity-modulated X-ray beams vs. intensity-modulated proton beams.
Int J Radiat Oncol Biol Phys. 2000 Jul 1;47(4):1111-9.
PMID: 10863085 [PubMed – indexed for MEDLINE]

Munzenrider JE., et al.
Conservative Treatment of Uveal Melanoma: Probability of Eye Retention after Proton Treatment.
Int. J. Radiation Oncology Biol. Phys. 1988; 15(3): 553-558.

Newhauser WD, Burns J, Smith AR.
Dosimetry for ocular proton beam therapy at the Harvard Cyclotron Laboratory based on the ICRU Report 59.
Med Phys. 2002 Sep;29(9):1953-61.
PMID: 12349914 [PubMed – indexed for MEDLINE]

Pfeiffer K, Bendl R.
Real-time dose calculation and visualization for the proton therapy of ocular tumours.
Phys Med Biol. 2001 Mar;46(3):671-86.
PMID: 11277216 [PubMed – indexed for MEDLINE]

Romani A, Baldeschi L, Genovesi-Ebert F, Gremigni E, Ragone MC, Rizzo S,
Nardi M.
Ultrasonographic and angiographic follow-up of primary choroidal malignant melanoma after proton beam irradiation therapy.
Ophthalmologica. 1998;212 Suppl 1:47-9.
PMID: 9730750 [PubMed – indexed for MEDLINE]

Romani A, Baldeshi L, Genovesi-Ebert F, Gremigni E, Ragone MC, Rizzo S,
Nardi M.
Ultrasonographic follow-up of primary choroidal malignant melanoma after proton beam irradiation therapy.
Ophthalmologica. 1998;212 Suppl 1:50-2.
PMID: 9730751 [PubMed – indexed for MEDLINE]

Stiefel S, Heufelder J, Pfaender M, Ludemann L, Grebe G, Hecse J.
BANG-polymer dosimetry in the proton therapy of eye neoplasms
Z Med Phys. 2004;14(1):48-54. German.
PMID: 15104010 [PubMed – indexed for MEDLINE]

Weber Damien C., et al.
Proton Beam Radiotherapy versus Fractionated Stereotactic Radiotherapy for Uveal Melanomas: A Comparative Study.
Int. J. Radiation Oncology Biol. Phys. 2005; 63(2): 373–384.

Wilson MW, Hungerford JL.
Comparison of episcleral plaque and proton beam radiation therapy for the treatment of choroidal melanoma.
Ophthalmology. 1999 Aug; 106(8):1759-87.
PMID: 10442907 [PubMed – indexed for MEDLINE]

Yock Torunn, et al.
Proton Radiotherapy for Orbital Rhabdomyosarcoma: Clinical Outcome and a Dosimetric Comparison with Photons.
Int. J. Radiation Oncology Biol. Phys. 2005; 63(4): 1161–1168.

Zur C, Caujolle JP, Chauvel, P, Dannon J, Iborra-Brassart N, Gastaud P.
Proton therapy of occult neovessels in age-related macular degeneration
J Fr Ophthalmol. 2001 Nov;24(9):949-54. French.
PMID: 11912839 [PubMed – indexed for MEDLINE]

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Head & Neck

Austin-Seymour M., et al.
Fractionated Proton Radiation Therapy of Chordoma and Low-Grade Chondrosarcoma of the Base of the Skull.
Journal of Neurosurgery. 1989 January; 70(1): 13-17.

Bauman GS, Wong E.
Re: new radiotherapy technologies for meningiomas: 3D conformal radiotherapy? Radiosurgery? Stereotactic radiotherapy? Intensity modulated radiotherapy? Proton beam radiotherapy? Spot scanning proton radiation therapy? Or nothing at all?
[Radiother Oncol 2004;71(3):247-249].
Radiother Oncol. 2004 Nov;73(2):251-2. No abstract available.
PMID: 15542173 [PubMed – in process]

Bolsi A, Fogliata A, Cozzi L.
Radiotherapy of small intracranial tumours with different advanced techniques using photon and proton beams: a treatment planning study.
Radiother Oncol. 2003 Jul;68(1):1-14.
PMID: 12885446 [PubMed – indexed for MEDLINE]

Bowyer J, Natha S, Marsh I, Foy P.
Visual complications of proton beam therapy for clival chordoma.
Eye. 2003 Apr;17(3):318-23.
PMID: 12724692 [PubMed – indexed for MEDLINE]

Cozzi L, Fogliata A, Lomax A, Bolsi A.
A treatment planning comparison of 3D conformal therapy, intensity modulated photon therapy and proton therapy for treatment of advanced head and neck tumours.
Radiother Oncol. 2001 Dec;61(3):287-97.
PMID: 11730999 [PubMed – indexed for MEDLINE]

Fitzck MM, Thornton AF, Varvares M, Ancukiewicz M, Mcintyre J, Adams J,
Rosenthal S, Joseph M, Amrein P.
Neuroendocrine tumors of the sinonasal tract. Results of a prospective study incorporating chemotherapy, surgery, and combined proton-photon radiotherapy.
Cancer. 2002 May 15;94(10):2623-34.
PMID: 12173330 [PubMed – indexed for MEDLINE]

Halperin EC.
Why is female sex an independent predictor of shortened overall survival after proton/photon radiation therapy for skull base chordomas?
Int J Radiat Oncol Biol Phys. 1997 May 1;38(2):225-30. Review. No abstract available.
PMID: 9226307 [PubMed – indexed for MEDLINE]

Hug EB, Slater JD.
Proton radiation therapy for chordomas and chondrosarcomas of the skull base.
Neurosurg Clin N Am. 2000 Oct;11(4):627-38. Review.
PMID: 11082173 [PubMed – indexed for MEDLINE]

Igaki H, Tokuuye K, Okumura T, Sugahara S, Kagei K, Hata M, Ohara K,
Hashimoto T, Tsuboi K, Takano S, Matsumura A, Akine Y.
Clinical Results of proton beam therapy for skull base chordoma.
Int J Radiat Oncol Biol Phys. 2004 Nov 15;60(4):1120-6. Review.
PMID: 15519783 [PubMed – indexed for MEDLINE]

Kamada K, Houkin K, Abe H, Sawamura Y, Kashiwaba T.
Differentiation of cerebral radiation necrosis from tumor recurrence by proton magnetic resonance spectroscopy.
Neurol Med Chir (Tokyo). 1997 Mar;37(3):250-6.
PMID: 9095625 [PubMed – indexed for MEDLINE]

Kaser-Hotz B, Sumova A, Lomax A, Schneider U, Klink B, Fidel J, Blattmann H.
A comparison of normal tissue complication probability of brain for proton and photon therapy of canine nasal tumors.
Vet Radiol Ultrasound. 2002 Sep-Oct;43(5):480-6.
PMID: 12375784 [PubMed – indexed for MEDLINE]

Lin R, Slater JD, Yonemoto LT, Grove RI, Teichman SL, Watt DK, Slater JM.
Nasopharyngeal carcinoma: repeat treatment with conformal proton therapy— dose-volume histogram analysis.
Radiology. 1999 Nov;213(2):489-94.
PMID: 10551231 [PubMed – indexed for MEDLINE]

Mirimanoff RO.
New radiotherapy technologies for meningiomas: 3D conformal radiotherapy? Radiosurgery? Stereotactic radiotherapy? Intensity-modulated radiotherapy? Proton beam radiotherapy? Spot scanning proton radiation therapy…or nothing at all?
Radiother Oncol. 2004 Jun;71(3):247-9. Review. No abstract available.
PMID: 15172138 [PubMed – indexed for MEDLINE]

Mock U, Georg D, Bogner J, Auberger T, Potter R.
Treatment planning comparison of conventional, 3D conformal, and intensitymodulated photon (IMRT) and proton therapy for paranasal sinus carcinoma.
Int J Radiat Oncol Biol Phys. 2004 Jan 1;58(1):147-54.
PMID: 14697432 [PubMed – indexed for MEDLINE]

Munzenrider JE, Liebsch NJ.
Proton therapy for tumors of the skull base.
Strahlenther Onkol. 1999 Jun;175 Suppl 2:57-63. Review.
PMID: 10394399 [PubMed – indexed for MEDLINE]

Noel G, Habrand JL, Mammar H, Pontvert D, Haie-Meder C, Hasboun D, Moisson P, Ferrand R, Beaudre A, Boisserie G, Gaboriaud G, Mazal A, Kerody K, Schlienger M, Mazeron JJ.
Combination of photon and proton radiation therapy for chordomas and chondrosarcomas of the skull base: the Centre de Protontherapie d’Orsay experience.
Int J Radiat Oncol Biol Phys. 2001 Oct 1;51(2):392-8.
PMID: 11567813 [PubMed – indexed for MEDLINE]

Noel G, Habrand JL. Mammar H, Haie-Meder C, Pontvert D, Dederke S, Ferrand R, Beaudre A, Gaboriaud G, Boisserie G, Mazeron JJ.
Highly conformal therapy using proton component in the management of meningiomas. Preliminary experience of the Centre de Protontherapie d’Orsay.
Strahlenther Onkol. 2002 Sep;178(9):480-5.
PMID: 12426833 [PubMed – indexed for MEDLINE]

No authors listed
Proton therapy for base of skull chordoma: a report for the Royal College of Radiologists. The Proton Therapy Working Party.
Clin Oncol (R Coll Radiol). 2000;12(2):75-9.
PMID: 10853741 [PubMed – indexed for MEDLINE]

Rutz Hans Peter, et al.
Extracranial Chordoma: Outcome in Patients Treated with Function-Preserving Surgery Followed by Spot-Scanning Proton Beam Irradiation.
Int. J. Radiation Oncology Biol. Phys. 2007; 67(2): 512–520.

Slater Jerry D., et al
Proton Radiation for Treatment of Cancer of the Oropharynx: Early Experience at Loma Linda University Medical Center Using a Concomitant Boost Technique.
Int. J. Radiation Oncology Biol. Phys. 2005l 62(2): 494–500.

Steneker M, Lomax A , Schneider U
Intensity modulated photon and proton therapy for the treatment of head and neck tumors.
Radiotherapy and Oncology. 2006; 80: 263–267.

Tokuuye K, Akine Y, Kagei K, Hata M, Hashimoto T, Mizumoto T, Ohshiro Y,
Suguhara S, Ohara K, Okumura T, Kusakari J, Yoshida H, Otsuka F.
Proton therpy for head and neck malignancies at Tsukuba.
Strahlenther Onkol. 2003 Feb;180(2):96-101.
PMID: 14762662 [PubMed – indexed for MEDLINE]

Vernimmen FJ, Harris JK, Wilson JA, Melvill R, Smit BJ, Slabbert JP.
Stereotactic proton beam therapy of skull base meningiomas.
Int J Radiat Oncol Biol Phys. 2001 Jan1;49(1):99-105.
PMID: 11163502 [PubMed – indexed for MEDLINE]

Weber DC, Chan AW, Bussiere MR, Harsh GR 4th, Ancukiewicz M, Barker FG 2nd, Thornton AT, Martuza RL, Nadol JB Jr, Chapman PH, Loeffler JS.
Proton beam radiosurgery for vestibular schwannoma; tumor control and cranial nerve toxicity.
Neurosurgery. 2003 Sep. 53(3):577-86; discussion 586-8.
PMID: 12943574 [PubMed – indexed for MEDLINE]

Weber DC, Lomax AJ, Rutz HP, Stadelmann O, Egger E, Timmermann B, Pedroni
ES, Verwey J, Miralbell R, Goitein G, Swiss Proton Users Group.
Spot-scanning proton radiation therapy for recurrent, residual or untreated intracranial meningiomas.
Radiother Oncol. 2004 Jun;71(3):251-8.
PMID: 15172139 [PubMed – indexed for MEDLINE]

Vernimmen Frederik J. A. I., et al.
Stereotactic Proton Beam Therapy for Intracranial Arteriovenous Malformations.
Int. J. Radiation Oncology Biol. Phys. 2005; 62(1): 44–52

Wenkel E, Thornton AF, Finkelstein D, Adams J, Lyons S, De La Monte S, Ojeman RG, Munzenrider JE.
Benign meniugioma; partially resected, biopsied, and recurrent intracranial tumors treated with combined proton and photon radiotherapy.
Int J Radiat Oncol Biol Phys. 2000 Dec 1;48(5):1363-70.
PMID: 11121635 [PubMed – indexed for MEDLINE]

Zurlo A.
Regarding “a treatment planning comparison of 3D conformal therapy, intensity modulated photon therapy and proton therapy for treatment of advanced head and neck tumours”.
Radiother Oncol. 2002 May;63(2):231. No abstract available.
PMID: 12063014 [PubMed – indexed for MEDLINE]

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Hodgkin’s Disease

Schneider U, Lomax A, Lombriser N.
Comparative risk assessment of secondary cancer incidence after treatment of Hodgkin’s disease with photon and proton radiation.
Radiat Res. 2000 Oct;154(4):382-8.
PMID: 11023601 [PubMed – indexed for MEDLINE]

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Liver

Ahmadi T, OkumuraT, Onaya H, Akine Y, Itai Y.
Preservation of hypervascularity in hepatocellular carcinoma after effective protonbeam radiotherapy – CT observation.
Clin Radiol. 1999 Apr;54(4):253-6.
PMIC: 10210346 [PubMed – indexed for MEDLINE]

Angiology; Proton beam therapy used in liver cancer with portal vein tumor Thrombus.
Medical Devices & Surgical Technology Week. 2005 October 9.

Bush DA, Hillebrand DJ, Slater JM, Slater JD.
High-dose proton beam radiotherapy of hepatocellular carcinoma: preliminary results of a phase II trial.
Gastroenterology. 2004 Nov;127(5 Suppl 1):S189-93.
PMID: 15508084 [PubMed – indexed for MEDLINE]

Gohongi T, Tokuuye K, Iida H, Nakai R, Gunji N, Akine Y, Orii K.
Concurrent proton beam radiotherapy and systemic chemotherapy for the metastatic liver tumor of gastric carcinoma: a case report.
Jpn J Clin Oncol. 2005 Jan:35(1):40-4.
PMID: 15681604 [PubMed – in process]

Kawashima M. Furuse J, Nishio T, Konishi M, Ishii H, Kinoshita T, Nagase M,
Nihei K, Ogino T.
Phase II study of radiotherapy employing proton beam for hepatocellular carcinoma.
J Clin Oncol. 2005 Mar 20;23(9):1839-46.
PMID: 15774777 [PubMed – indexed for MEDLINE]

Ohara K, Okumura T, Tsuji H, Min M, Tatsuzaki H, Chiba T, Tsujii H, Akine Y, Itai
Y.
Clearance of parenchymal tumors following radiotherapy: analysis of hepatocellular carcinomas treated by proton beams.
Radiother Oncol. 1996 Dec;41(3):233-6.
PMID: 9027939 [PubMed – indexed for MEDLINE]

Ohara K, Okumura T, Tsuji J, Chiba T, Min M, Tatsuzaki H, Tsujii H, Akine Y, Itai
Y.
Radiation tolerance of cirrhotic livers in relation to the preserved functional capacity: analysis of patients with hepatocellular carcinoma treated by focused proton beam radiotherapy.
Int J Radiat Oncol Biol Phys. 1997 May 1;38(2):367-72.
PMID: 9226325 [PubMed – indexed for MEDLINE]

Onaya H, Itai Y, Yoshioka H, Ahmadi T, Niitsu M, Okumura T, Akine Y, Matsuzaki
Y, Doi M, Tsuji H, Tsujii H.
Changes in the liver parenchyma after proton beam radiotherapy: evaluation with MR imaging.
Magn Reson Imaging. 2000 Jul;18(6):707-14.
PMID: 10930780 [PubMed – indexed for MEDLINE]

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Lung

Bonnet RB, Bush D, Cheek GA, Slater JD, Panossian D, Franke C, Slater JM.
Effects of proton and combined proton/photon beam radiation on pulmonary function in patients with resectable but medically inoperable non-small cell lung cancer.
Chest. 2001 Dec;120(6):1803-10.
PMID: 11742905 [PubMed – indexed for MEDLINE]

Bush DA, Dunbar RD, Bonnet R, Slater JD, Cheek GA, Slater JM.
Pulmonary injury from proton and conventional radiotherapy as revealed by CT.
AJR Am J Roentgenol. 1999 Mar;172(3):735-9.
PMID: 10063841 [PubMed – indexed for MEDLINE]

Bush DA, Slater JD, Bonnet R, Cheek GA, Dunbar RD, Moyers M. Slater JM.
Proton-beam radiotherapy for early-stage lung cancer.
Chest. 1999 Nov;116(5):1313-9.
PMID: 10559093 [PubMed – indexed for MEDLINE]

Bush DA, Slater JD, Shin BB, Cheek G, Miller DW, Slater JM.
Hypofractionated proton beam radiotherapy for stage I lung cancer.
Chest. 2004 Oct;126(4):1198-203.
PMID: 15486383 [PubMed – indexed for MEDLINE]

Chang Joe Y., et al.
Significant Reduction of Normal Tissue Dose by Proton Radiotherapy Compared with Three-Dimensional Conformal or Intensity-Modulated Radiation Therapy in Stage I or Stage III Non-Small-Cell Lung Cancer.
Int. J. Radiation Oncology Biol. Phys. 2006; 65(4): 1087–1096.

Hata Masaharu, et al.
Hypofractionated High-Dose Proton Beam Therapy for State I Non-Small-Cell Lung Cancer: Preliminary Results of a Phase I/II Clinical Study.
Int. J. Radiation Oncology Biol. Phys. 2007; 68(3): 786–793.

Gridley DS, Bonnet RB, Bush DA, Franke C, Cheek GA, Slater JD, Slater JM.
Time course of serum cytokines in patients receiving proton or combined photon/proton beam radiation for respectable but medically inoperable non-small cell lung cancer.
Int J Radiat Oncol Biol Phys. 2004 Nov 1;60(3):759-66.
PMID: 15465192 [PubMed – indexed for MEDLINE]

Kang, Yixiu, et al.
4D Proton Treatment Planning Strategy for Mobile Lung Tumors.
Int. J. Radiation Oncology Biol. Phys., 2007; 67(3): 906–914.

Lee CH, Tait D, Nahum AE, Webb S.
Comparison of proton therapy and conformal X-ray in non-small cell lung cancer
Br J Radiol. 1999 Nov;72(863):1078-84.
PMID: 10700825 [PubMed – indexed for MEDLINE]

Nihei Keiji, Ogino Takashi, Ishikura Satoshi and Nishimura Hideki.
High-Dose Proton Beam Therapy for Stage I Non-Small –Cell Lung Cancer.
Int. J. Radiation Oncology Biol. Phys. 2006; 65(1): 107–111.

Ogino T.
Proton beam radiotherapy for lung cancer
Nippon Rinsho. 2002 May;60 Suppl 5:419-22. Review. Japanese. No abstract available.
PMID: 12101704 [PubMed – indexed for MEDLINE]

Shioyama Y, Tokuuye K, Okumura T, Kagei K, Sugahara S, Ohara K, Akine Y,
Ishikawa S, Satoh H, Sekizawa K.
Clinical evaluation of proton radiotherapy for non-small-cell lung cancer.
Int J Radiat Oncol Biol Phys. 2003 May 1:56(1):7-13.
PMID: 12694818 [PubMed – indexed for MEDLINE]

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Nerve

Bhattacharyya N, Thornton AF, Joseph MP, Goodman ML, Amrein PC.
Successful treatment of esthesioneuroblastoma and neuroendocrine carcinoma with combined chemotherapy and proton radiation. Results in 9 cases.
Arch Otolaryngol Head Neck Surg. 1997 Jan;123(1):34-40.
PMID: 9006501 [PubMed – indexed for MEDLINE]

Bush DA, McAllister CJ, Loredo LN, Johnson WD, Slater JM, Slater JD.
Fractionated proton beam radiotherapy for acoustic neuroma.
Neurosurgery. 2002 Feb;50(2):270-3; discussion 273-5.
PMID: 11844261 [PubMed – indexed for MEDLINE]

Hug EB, Nevinny-Stickel M, Fuss M, Miller DW, Schaefer RA, Slater JD.
Conformal proton radiation treatment for retroperitoneal neuroblastoma: introduction of a novel technique.
Med Pediatr Oncol. 2001 Jul;37(1):36-41.
PMID: 11466721 [PubMed – indexed for MEDLINE]

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Pancreas

Hsiung-Stripp DC, McDonough J, Masters HM, Levin WP, Hahn SM, Jones HA,
Metz JM.
Comparative treatment planning between proton and X-ray therapy in pancreatic cancer.
Med Dosim. 2001 Fall;26(3):255-9.
PMID: 11704461 [PubMed – indexed for MEDLINE]

Zurlo A, Lomax A, Hoess A, Bortfeld T, Russo M, Goitein G, Valentini V, Marucci
L, Capparella R, Loasses A.
The role of proton therapy in the treatment of large irradiation volumes: a comparative planning study of pancreatic and biliary tumors.
Int J Radiat Oncol Biol Phys. 2000 Aug 1;48(1):277-88.
PMID: 10924999 [PubMed – indexed for MEDLINE]

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Children/Pediatric

Fuss M, Hug EB, Schaefer RA, Nevinny-Stickel M, Miller DW, Slater JM, Slater
JD.
Proton radiation therapy (PRT) for pediatric optic pathway gliomas: comparison with 3D planned conventional photons and a standard photon technique.
Int J Radiat Oncol Biol Phys. 1999 Dec 1;45(5):1117-26.
PMID: 10613303 [PubMed – indexed for MEDLINE]29

Habrand JL, Mammar H, Ferrand R, Pontvert D, Bondiau PY, Kalifa C, Zucker JM.
Proton beam therapy (PT) in the management of CNS tumors in childhood.
Strahlenther Onkol. 1999 Jun;175 Suppl 2:91-4.
PMID: 10394410 [PubMed – indexed for MEDLINE]

Hug EB, Muenter MW, Archambeau JO, DeVries A, Liwnicz B, Loredo LN, Grove
RI, Slater JD.
Conformal proton radiation therapy for pediatric low-grade astrocytomas.
Strahlenther Onkol. 2002 Jan;178(1):10-7.
PMID: 11977386 [PubMed – indexed for MEDLINE]

Hug EB, Slater JD.
Proton radiation therapy for pediatric malignancies: status report.
Strahlenther Onkol. 1999 Jun;175 Suppl 2:89-91.
PMID: 10394409 [PubMed – indexed for MEDLINE]

Hug EB, Sweeney RA, Nurre PM, Holloway KC, Slater JD, Munzenrider JE.
Proton radiotherapy in management of pediatric base of skull tumors.
Int J Radiat Oncol Biol Phys. 2002 Mar 15;52(4):1017-24.
PMID: 11958897 [PubMed – indexed for MEDLINE]

Kirsch DG, Tarbell NJ.
New technologies in radiation therapy for pediatric brain tumors: the rationale for proton radiation therapy.
Pediatr Blood Cancer. 2004 May;42(5):461-4. Review.
PMID: 15049021 [PubMed – indexed for MEDLINE]

Lee, Catherine T., et al.
Treatment Planning with Protons for Pediatric Retinoblastoma, Medulloblastoma, and Pelvic Sarcoma: How Do Protons Compare with Other Conformal Techniques?
Int. J. Radiation Oncology Biol. Phys. 2005. 63(2): 362–372.

Lundkvist J, Ekman M, Ericsson SR, Jonsson B, Glimelius B.
Cost-effectiveness of proton radiation in the treatment of childhood medulloblastoma.
Cancer. 2005 Feb 15;103(4):793-801.
PMID: 15637691 [PubMed – in process]

McAllister B, Archambeau JO, Nguyen MC, Slater JD, Loredo L, Schulte R, Alvarez
O, Bedros AA, Kalcita T, Moyers M, Miller D, Slater JM.
Proton therapy for pediatric cranial tumors: preliminary report on treatment and disease-related morbidities.
Int J Radiat Oncol Biol Phys. 1997 Sep 1;39)2):455-60.
PMID: 9308950 [PubMed – indexed for MEDLINE]

Miralbell R, Lomax A, Russo M.
Potential role of proton therapy in the treatment of pediatric medulloblastoma/primitive neuro-ectodermal tumors: spinal theca irradiation.
Int J Radiat Oncol Biol Phys. 1997 Jul 1;38(4):805-11.
PMID: 9240650 [PubMed – indexed for MEDLINE]

Miralbell R, Lomax A, Cella L, Schneider U.
Potential reduction of the incidence of radiation-induced second cancers by using proton beams in the treatment of pediatric tumors.
Int J Radiat Oncol Biol Phys. 2002 Nov 1;54(3):824-9.
PMID: 12377335 [PubMed – indexed for MEDLINE]

Noel G, Habrand, JL, Helfre S, Mammar H, Halifa C, Ferrand R, Beaudre A,
Gaboriaud G, Mazeron JJ.
Proton beam therapy in the management of central nervous system tumors in childhood: the preliminary experience of the Centre de Protontherapie d’Orsay.
Med Pediatr Oncol. 2003 May;40(5):309-15.
PMID: 12652619 [PubMed – indexed for MEDLINE]

St. Clair W. H., et al.
Advantage of Protons Compared to Conventional X-Ray or IMRT in the Treatment of Pediatric Patient with Medulloblastoma.
Int. J. Radiation Oncology Biol. Phys. 2004; 58(3): 727–734

Taylor RE.
Proton radiotherapy for paediatric tumours: potential areas for clinical research.
Clin Oncol (R Coll Radiol). 2003 Feb;15(1):S32-6.
PMID: 12602562 [PubMed – indexed for MEDLINE]

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Prostate

Cella L, Lomax A, Miralbell R.
Potential role of intensity modulated proton beams in prostate cancer radiotherapy.
Int J Radiat Oncol Biol Phys. 2001 Jan1;49(1):217-23.
PMID: 11163518 [PubMed – indexed for MEDLINE]

Hara I, Murakami M, Kagawa K, Sugimura K, Kamidono S, Hishikawa Y, Abe M.
Experience with conformal proton therapy for early prostate cancer.
Am J Clin Oncol. 2004 Aug;27(4):323-7.
PMID: 15289722 [PubMed – indexed for MEDLINE]

Mock Ulrike, et al.
Comparative Treatment Planning on Localized - Prostate Carcinoma Conformal Photon- versus Proton-Based Radiotherapy.
Strahlenther Onkol. 2005; 7: 448-455

Rossi CJ.
Conformal proton beam therapy of prostate cancer—update on the Loma Linda University medical center experience.
Strahlenther Onkol. 1999 Jun;175 Suppl 2:82-4.
PMID: 10394403 [PubMed – indexed for MEDLINE]

Rossi CJ Jr, Slater JD, Yonemoto LT, Jabola BR, Bush DA, Levy RP, Grove R,
Slater JM.
Influence of patient age on biochemical freedom from disease in patients undergoing conformal proton radiotherapy of organ-confined prostate cancer.
Urology. 2004 Oct;64(4):729-32.
PMID: 15491710 [PubMed – in process]

Schulte RW, Slater JD, Rossi CJ Jr, Slater JM.
Value and perspectives of proton radiation therapy for limited stage prostate cancer.
Strahlenther Onkol. 2000 Jan;176(1):3-8.
PMID: 10650829 [PubMed – indexed for MEDLINE]

Slater JD, Rossi CJ Jr, Yonemoto LT, Bush DA, Jabola BR, Levy RP, Grove RI,
Preston W, Slater JM.
Proton therapy for prostate cancer: the initial Loma Linda University experience.
Int J Radiat Oncol Biol Phys. 2004 Jun 1;59(2):348-52.
PMID: 15145147 [PubMed – indexed for MEDLINE]

Slater JD, Rossi CJ Jr, Yonemoto LT, Reyes-Molyneux NJ, Bush DA, Antoine JE,
Miller DW, Teichman SL, Slater JM.
Conformal proton therapy for early-stage prostate cancer.
Urology. 1999 May;53(5):978-84.
PMID: 10223493 [PubMed – indexed for MEDLINE]

Slater JD, Yonemoto LT, Rossi CJ Jr, Reyes-Molyneux NJ, Bush DA, Antoine JE,
Loredo LN, Schulte RW, Teichman SL, Slater JM.
Conformal proton therapy for prostate carcinoma.
Int J Radiat Oncol Biol Phys. 1998 Sep 1;42(2):299-304.
PMID: 9788407 [PubMed – indexed for MEDLINE]

Smith JA Jr.
Proton therapy for prostate cancer: The initial Loma Linda University experience.
Slater JD, Rossi CJ Jr, Yonemoto LT, Bush DA, Jabola BR, Levy RP, Grove RI, Preston
W, Slater JM, Department of Radiation Medicine, Loma Linda University Medical
Center, Loma Linda, CA Int J Radiat Oncol Biol Phys. 2004;59:348-52.
Urol Oncol. 2004 Nov-Dec;22(6):494-5.
PMID: 15610869 [PubMed – in process]

Yonemoto LT, Slater JD, Rossi CJ Jr. Antoine JE, Loredo L. Archambeau JO,
Schulte RW, Miller DW, Teichman SL, Slater JM.
Combined proton and photon conformal radiation therapy for locally advanced carcinoma of the prostate; preliminary results of a phase I/II study.
Int J Radiat Oncol Biol Phys. 1997 Jan 1;37(1):21-9.
PMID: 9054873 [PubMed – indexed for MEDLINE]

Zietman AL, et al.
Comparison of Conventional-Dose vs High-Dose Conformal Radiation Therapy in Clinically Localized Adenocarcinoma of the Prostate A Randomized Controlled.
JAMA. 2005 September 14; 294(10): 1233-39.

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Rectum

Isacsson U, Montelius A, Jung B, Glimelius B.
Comparative treatment planning between proton and X-ray therapy in locally advanced rectal cancer.
Radiother Oncol. 1996 Dec;41(3):263-72.
PMID: 9027943 [PubMed – indexed for MEDLINE]

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Spine

Weber DC, Trofimov AV, Delaney TF, Bortfeld T.
A treatment planning comparison of intensity modulated photon and proton therapy for paraspinal sarcomas.
Int J Radiat Oncol Biol Phys. 2004 Apr 1;58(5):1596-606.
PMID: 15050341 [PubMed – indexed for MEDLINE]

 

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